The natural antioxidant extract from the Klamath microalgae
Targeted action against inflammation and oxidative stress:
- Antioxidant power six times higher than quercetin.
- Proven, secure, and documented effectiveness
- 100% natural and proprietary extract
What is AphaMax®
AphaMax® is a patented extract (EP Nr. 2032122B1) from the Klamath microalgae, standardized in AFA-phycocyanins, with a concentration four times higher than that of whole algae 1. Extraction is achieved by mechanically opening the microalgal cells and extracting them in water, without the use of chemical solvents 2.
The Klamath microalgae contains approximately 6-8% AFA-phycocyanin, while the extract concentrates it to approximately 25-30%. The remainder consists of the natural water-soluble fraction of the Klamath microalgae: trace elements, amino acids, polyphenols, algal mycosporins, vitamins, etc. 1
The fact that AphaMax® is a concentrated extract, rather than an isolated compound, allows it to maintain a complex nutritional matrix, typical of the original microalgae.
HOW IT WORKS
AphaMax® has been the subject of numerous preclinical scientific studies, which have examined the properties of AFA-phycocyanins extracted from the Klamath microalgae. 3 ,4,5
Scientific literature reports the use of the extract in experimental intestinal and skin models, with evidence and positive results observed in the study settings. 6,7,8,9
From an analytical standpoint, AphaMax® demonstrated marked antioxidant capacity in vitro, assessed by ORAC assay, with values significantly higher than the references used in the study, such as quercetin. 5
Aphamax® extract
AphaMax® Nutrigea is an inflammatory, metabolic, and cellular modulator with a profound, documented, and safe action profile 10.
It is used in advanced formulations where it fully expresses its systemic potential.
Scientific Evidence
BIBLIOGRAPHY
1 G D. Scoglio, et al., (2024). The commercial potential of Aphanizomenon flos-aquae, a nitrogen-fixing edible cyanobacterium, Journal of Applied Phycology, Volume 36, pages 1593-1617 (2024).
2 S. Scoglio, G D. Scoglio, (2024) Klamath Lake Aphanizomenon Flos-Aquae: Wild-Harvesting, Extracts and Benefits. Vol. Insights Into Algae – Fundamentals, Culture Techniques and Biotechnological Uses of Microalgae and Cyanobacteria.
3 S. Benedetti, S. Rinalducci, et al., (2006) Purification and characterization of phycocyanin from the blue-green alga Aphanizomenon flos-aquae. Journal of Chromatography B, Volume 833, Issue 1, Pages 12-18.
4 Benedetti S, Scoglio S, et al., (2010). Oxygen radical absorbance capacity of phycocyanin and phycocyanobilin from the food supplement Aphanizomenon flos-aquae. J Med Food. 13(1):223-7
5 Benedetti S., Scoglio S., et al. (2004). Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae. Life Sci. 75(19):2353-62.
6 M G. Zizzo, S. Scoglio, et al., AphaMax®, an Aphanizomenon Flos-Aquae Aqueous Extract, Exerts Intestinal Protective Effects in Experimental Colitis in Rats. 26 November 2020, Nutrients 2020, 12(12), 3635
7 A. Amato, S. Scoglio, et al., Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility. 28 September 2021, Nutrients 2021, 13(10), 3445
8 Canestrari F. et al., Antinflammatory properties of phycocyanin from Aphanizomenon flos-aquae. Progress in Nutrition, Vol. 8, n.2 (2006), pp. 99-103.
9 Cavalchini A., Scoglio S., Complementary Treatment of Psoriasis with an AFA-phycocyanins product: a preliminary 10-cases study, International Medical Journal, Vol. 16, 3, pp. 221-4, Sept. 2009
10 F Naselli, G D. Scoglio, et al., First evidence of epigenetic modulation of human gene methylation by microalga Aphanizomenon flos-aquae (AFA) in inflammation-related pathways in intestinal cells, 06 March 2025, Volume 17, article number 44, (2025).