The natural neuromodulatory extract from the Klamath microalgae
To rebalance the nervous system and mood
- Powerful regenerative action
- Proven, secure, and documented effectiveness
- 100% natural and proprietary extract
What is Klamin
Extraction is achieved by mechanically opening the microalgal cells and extracting them in water, followed by an ultrafiltration process, without the use of chemical solvents 2
The Klamin extract
The Klamath microalgae contains approximately 0.3-0.5% PEA, while the extract concentrates it to approximately 1.5%. The remainder consists of the ultrafiltered water-soluble fraction of the Klamath microalgae 1
Klamin® also concentrates a characteristic series of compounds naturally present in the microalgae, including algal microsporins (MAAs) and AFA-phytochromes, studied for their interaction with the MAO-B enzyme, involved in the degradation processes of phenylethylamine, resulting in greater biological persistence of PEA over time 3
The fact that Klamin® is a concentrated extract, rather than an isolated compound, allows for the maintenance of a complex nutritional matrix, typical of the original microalgae.
Properties
Phenylethylamine (PEA) is a widely studied endogenous compound in neuroscience, involved in neurotransmitter regulation mechanisms 4
Several scientific studies have analyzed the Klamin® extract in experimental models, highlighting consistent and reproducible results of interest in research on the neuroendocrine system and cognitive processes 5, 6, 7, Its action is adaptogenic and regulatory, without forcing or sedating..
In preclinical studies, the extract has been associated with changes in biological parameters related to neuronal function, including markers involved in memory and learning processes 8, 9
Klamin® Nutrigea is not just a mood supplement: it contains a neuromodulator with documented effects on cognitive function, mental resilience, and neuronal regeneration, in total harmony with the body’s mechanisms.
Scientific Evidence
BIBLIOGRAPHY
1 G D. Scoglio, et al., (2024). The commercial potential of Aphanizomenon flos-aquae, a nitrogen-fixing edible cyanobacterium, Journal of Applied Phycology, Volume 36, pages 1593-1617 (2024).
2 S. Scoglio, G D. Scoglio, (2024) Klamath Lake Aphanizomenon Flos-Aquae: Wild-Harvesting, Extracts and Benefits. Vol. Insights Into Algae – Fundamentals, Culture Techniques and Biotechnological Uses of Microalgae and Cyanobacteria.
3 Scoglio S, Benedetti Y, Benvenuti F, Battistelli S, Canestrari F, Benedetti S (2014) Selective monoamine oxidase B inhibition by an Aphanizomenon flos-aquae extract and by its constitutive active principles phycocyanin and mycosporine-like amino acids. Phytomedicine 21:992–997
4 Irsfeld M, Spadafore M, Prüß BM (2013) β-Phenylethylamine, a small molecule with a large impact. Webmedcentral 4:4409
5 Genazzani AD, Chierchia E, Lanzoni C, Santagni S, Veltri F, Ricchieri F, Rattighieri E, Nappi RE (2010) Effects of Klamath Algae extract on psychological disorders and depression in menopausal women: a pilot study. Minerva Ginecology 62:381–388
6 Cremonte M, Sisti D, Maraucci I, Giribone S, Colombo E, Rocchi MBL, Scoglio S (2017) The effect of experimental supplementation with the klamath algae extract klamin on attention-deficit/hyperactivity disorder. J Med Food 20:1233–1239
7 Bellingeri P., Scoglio S., Bonucci M., (2018). Complementary Treatment of Mood Disturbances in Terminally Ill Oncological Patients with the Aphanizomenon Flos Aquae Extract Klamin®, Adv Complement Alt Med. 1(3).
8 Sedriep S. et al., (2011) Beneficial nutraceutical modulation of cerebral erythropoietin expression and oxidative stress: an experimental study, J Biol Regul Homeost Agents. 25(2):187-94.
9 Nuzzo D, Presti G, Picone P, Galizzi G, Gulotta E, Giuliano S, Mannino C, Gambino V, Scoglio S, Di Carlo M (2018) Effects of the Aphanizomenon flos-aquae extract (klamin®) on a neurodegeneration cellular model. Oxidat Med Cell Longev 2018:9089016.