Natural-source vitamin B12, Klamin® from Klamath microalgae, betaine, zinc, vitamin B6 and folate (vitamin B9) from plant, algal and fungal sources: nutrients involved in energy metabolism and in the normal functioning of the nervous system and immune system, helping to reduce tiredness and fatigue caused by a deficiency of B vitamins.
Format: Case - Blister pack of 30 tablets
Directions for use: Take 1-2 tablets a day, with meals.
B 12 -Natural® is a vitamin B12 supplement in the form of biologically active coenzymes – extracted from the marine algae Porphyra umbilicalis , one of the few natural sources of biologically active vitamin B12 documented in literature [1-2] .
These coenzymes are readily available , as they provide vitamin B12 in coenzyme forms (methyl- and adenosylcobalamin), which are already biologically active [3].
Vitamin B12 functions as an essential cofactor in key processes of cellular metabolism, including the conversion of methylmalonyl-CoA to succinyl-CoA and the methionine cycle. These mechanisms are central to energy production and cellular methylation processes [4].
Vitamin B12 (cobalamin) contributes to normal energy-yielding metabolism , normal functioning of the nervous system , normal functioning of the immune system , normal red blood cell formation , normal cell division , and the reduction of tiredness and fatigue . It also contributes to normal homocysteine metabolism [5-6].
Unlike single-component supplements, B 12 -Natural® is conceived as a synergy of nutrients: vitamin B12 is inserted into an algal and vegetal matrix which provides the key cofactors of its metabolism – betaine , vitamin B6 , folates – useful for the control of homocysteine [7-8].
Klamin® , a patented extract from Klamath algae ( EU Patent No. 2046354 ), provides β-phenylethylamine (PEA) and natural antioxidants. Experimental studies have further investigated the antioxidant action of Klamin®, highlighting a protective effect against oxidative stress in a neuronal cellular model[9] . <A clinical study on vegan subjects demonstrated that vitamin B12 from Klamath algae contributed to the reduction of homocysteine levels [10].
The fermentative enzyme complexes present in the formula (Protexil® SP750 and EnzyBlend®) have been studied to support the digestion of nutrients [11].
B12-Natural® complex acts synergistically on multiple physiological dimensions: energy metabolism, neurofunctional balance, immune function and cellular methylation processes.
The natural formula is also suitable for those following a vegan and vegetarian diet.
The natural ingredients of the B12-Natural® Nutrigea supplement can be useful as:
The B12-Natural® supplement is naturally gluten and lactose free.
Porphyra umbilicalis Kützing thallus extract (0.1% vitamin B12 [cobalamin of natural origin]), Klamin® extract from Klamath microalgae (Aphanizomenon flos aquae), bulking agent: acacia gum; Beta vulgaris L. root extract (60% betaine), Aquamin (Lithothamnion calcareum algae thallus), pregelatinized corn starch, Shiitake (Lentinula edodes (Berk.) Pegler) mushroom fruiting body extract (5% zinc), Solanum tuberosum L. tuber extract (10% vitamin B6), anti-caking agent: glycerol behenate; Protexil® SP750 enzyme complex from fermented plant substrates with Aspergillus oryzae (Protease), EnzyBlend® enzyme complex from fermented plant substrates with Aspergillus oryzae, Aspergillus niger and Rhizopus oryzae (Amylase, Glucoamylase, Protease, Lactase, Pectinase, Cellulase, Lipase), Spinacia oleracea L. leaves es (10% folates).
Do not exceed the recommended daily dose. Keep out of reach of children under three years of age. Supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store in a cool, dry place.
1 Watanabe F, et al. “Vitamin B12-containing plant food sources for vegetarians.” Nutrients, 2014; 6(5):1861–1873. DOI: 10.3390/nu6051861
2 Watanabe F. et al., 2000 – Characterization of a vitamin B12 compound in the edible purple laver, Porphyra yezoensis
3 Peter Lyon et al., B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease Nutrients. 2020 Sep 19;12(9):2867. doi: 10.3390/nu12092867
4 Stabler SP., NEJM 2013 – Vitamin B12 deficiency e Lyon et al., Nutrients 2020 – One-carbon metabolism
5 Stabler SP. “Vitamin B12 deficiency.” N Engl J Med, 2013; 368(2):149–160. DOI: 10.1056/NEJMcp1113996
6 Reynolds E. “Vitamin B12, folic acid, and the nervous system.” Lancet Neurol, 2006; 5(11):949–960. DOI: 10.1016/S1474-4422(06)70598-1
7 Olthof MR, Verhoef P. “Effects of betaine intake on plasma homocysteine concentrations and consequences for health.” Curr Drug Metab, 2005; 6(1):15–22. DOI: 10.2174/1389200052997443
8 Bailey LB, Gregory JF 3rd. “Folate metabolism and requirements.” J Nutr, 1999; 129(4):779–782. DOI: 10.1093/jn/129.4.779
9 Nuzzo D, Presti G, Picone P, et al. Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model. Oxid Med Cell Longev. 2018;2018:9089016. Published 2018 Sep 17. doi:10.1155/2018/9089016
10 Baroni L, et al. “Effect of a Klamath algae product (“AFA-B12″) on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study.” Int J Vitam Nutr Res, 2009; 79(2):117–123. DOI: 10.1024/0300-9831.79.2.117
11 Ianiro G. et al., 2016 – Digestive Enzyme Supplementation in Gastrointestinal Diseases
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