COSMECEUTICALS

Dermax® Plus Cream

Provides relief and comfort to the skin.
Dermax® Plus Cream is a gel-cream with a high concentration of phycocyanins , formulated with Klamath microalgae, shea butter and selected vegetable oils to soothe reactive skin, provide relief and promote a sensation of comfort and skin well-being, even in the most delicate situations.

Format: Box – 50 ml bottle

Directions for use:

Apply a small amount to the affected areas, massaging gently until completely absorbed. Use as needed to promote relief and comfort.

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Dermax® Plus Cream is a dermatological gel-cream with a soothing and calming effect , designed to promote skin comfort, when the skin experiences redness, heat, itching or sensations of discomfort that require immediate relief.

At the heart of the formula are phycocyanins , water-soluble protein-pigments extracted from the Klamath microalgae (Aphanizomenon flos-aquae). Phycocyanins represent the active and distinctive element of Dermax® Plus Cream [1,2,3].

Phycocyanins are studied for their antioxidant activity and their role in modulating mechanisms associated with skin inflammation. At the molecular level, they modulate redox-sensitive pathways such as COX-2 and NF-κB and exhibit antioxidant activity against reactive oxygen species (ROS) [2,3]. This contributes to maintaining the balance of the skin microenvironment in conditions of increased sensitivity and discomfort.

The efficacy of phycocyanins is enhanced by the synergy with tocopherol and ascorbyl palmitate , which protect membrane phospholipids from peroxidation. The alkylamides of Zanthoxylum bungeanum are studied for their involvement in the transmission mechanisms of itch and cutaneous neurosensory discomfort [4].

Geranium monoterpenes ( citronellol, geraniol) and patchouli patchoulol complete the formula’s sensory and functional profile, while bitter orange floral water provides freshness and delicacy. The skin-friendly lipid matrix —rich in medium-chain triglycerides, shea butter , macadamia oil , and lecithin —promotes the cohesion of the stratum corneum, provides softness , and supports the integrity of the skin barrier [5,6,7].

The gel-cream texture absorbs quickly, provides relief and helps improve the feeling of well-being even in the most sensitive and fragile skin.

Dermax® Plus Cream is part of the integrated Dermax® dermatological program , composed of Dermax® Capsules (systemic action on the biological terrain) and Dermax® Plus Cream (local soothing and calming action), for complete support for sensitive, reactive or irritation-prone skin.

Dermax® Plus Cream is indicated as a soothing cosmetic treatment for skin subject to:

  • Red, hot, reactive, irritated, sensitized or fragile skin
  • Itching, burning or a sensation of heat
  • Skin prone to flaking, irritation and redness
  • Reactive skin with redness and itching
  • Blemish-prone skin with discomfort and a tendency to inflammation
  • Skin stress and exposure to oxidative or environmental factors

Ideal when the skin needs immediate relief and a targeted soothing intervention to regain comfort and well-being.

Aqua, Caprylic/Capric Triglyceride, Glycerin, Citrus Aurantium Amara Flower Water, Macadamia Ternifolia Seed Oil, Butyrospermum Parkii Butter, Dicaprylyl Ether, Penthylene Glycol, Sodium Acrylates Copolymer, Oleyl Alcohol, Lecithin, Hydroxyacetophenone, Aphanizomenon Flos Aquae Extract, Aphanizomenon Flos Aquae Powder, Zanthoxylum Bungeanum Fruit Extract, Pelargonium Graveolens Flower Oil*, Pogostemon Cablin Oil*, Polysorbate 80, Sodium Phytate, Tocopherol, Ascorbyl Palmitate, Citric Acid, Potassium Sorbate, Sodium Benzoate, Beta-Caryophyllene*, Citral*, Citronellol*, d-Limonene*, Geraniol*, Geranyl Acetate*, Linalool*, Pinene*, Terpineol*.

(*) allergenic substances EU Reg. 1545/2023

Avoid contact with eyes. Keep out of reach of children. Cosmetic product for external use only.

  1. Scoglio S, Benedetti S, Canino C, Santagni S, Rattighieri E, Chierchia E, Canestrari F, Genazzani AD. Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women. Gynecol Endocrinol. 2009 Apr;25(4):235-40. doi: 10.1080/09513590802632506. PMID: 19408172.
  2. Reddy CM, Bhat VB, Kiranmai G, Reddy MN, Reddanna P, Madyastha KM. Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis. Biochem Biophys Res Commun. 2000 Nov 2;277(3):599-603. doi: 10.1006/bbrc.2000.3725. PMID: 11062000.
  3. Cherng SC, Cheng SN, Tarn A, Chou TC. Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages. Life Sci. 2007 Oct 27;81(19-20):1431-5. doi: 10.1016/j.lfs.2007.09.009. Epub 2007 Sep 25. PMID: 17961604.
  4. Koo JY, Jang Y, Cho H, Lee CH, Jang KH, Chang YH, Shin J, Oh U. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26(5):1139-47. doi: 10.1111/j.1460-9568.2007.05743.x. PMID: 17767493.
  5. Rajkumar J, Chandan N, Lio P, Shi V. The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair. Skin Pharmacol Physiol. 2023;36(4):174-185. doi: 10.1159/000534136. Epub 2023 Sep 15. PMID: 37717558.
  6. Rosso JD, Zeichner J, Alexis A, Cohen D, Berson D. Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner: Proceedings of an Expert Panel Roundtable Meeting. J Clin Aesthet Dermatol. 2016 Apr;9(4 Suppl 1):S2-S8. Epub 2016 Apr 1. PMID: 28936279; PMCID: PMC5608132.
  7. Yang L, Mao-Qiang M, Taljebini M, Elias PM, Feingold KR. Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment. Br J Dermatol. 1995 Nov;133(5):679-85. doi: 10.1111/j.1365-2133.1995.tb02738.x. PMID: 8555016.

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Vegan-friendly
Gluten free product
Product containing Klamin® extract
Product containing Klamin® extract
Product containing AphaMax® extract
Product containing Aphamax® extract
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