KlamUp® Nutrigea is a nutraceutical supplement containing Klamath algae, Rhodiola rosea and saffron, ingredients that support key neurofunctional systems. Its formula promotes concentration, emotional balance and the ability to adapt to mental and psychophysical demands.
Format: Case - Blister pack of 30 tablets
Directions for use: 1 tablet 2 times a day, away from meals.
The KlamUp® Nutrigea formula was created to address one of the most common needs of modern life: maintaining clarity, emotional stability, and mental continuity even under prolonged pressure and cognitive fatigue.
Its formulation combines three extracts selected for their complementary and documented action:
• Klamin® (from Klamath algae), rich in phenylethylamine (PEA), helps support the natural neurobiological processes associated with dopamine, serotonin, and norepinephrine, promoting mental tone, motivation, and emotional resilience. The extract’s components also support the physiological mechanisms of neuronal protection and cognitive adaptation.1,2,3,4,5,6,7
• Rhodiola rosea (rosavins and salidroside) contributes to the body’s normal adaptation to stress, supporting neuroendocrine balance and cellular energy production. It thus promotes resistance to mental fatigue and supports the continuity of neurofunctional activity.8,9,10
• Saffron (safranal and crocin) contributes to emotional well-being by physiologically modulating the serotonergic and GABAergic systems, promoting alert calm and balance without sedative effects.11,12,13
It also supports processes related to neuronal plasticity.
Thanks to this synergy,the KlamUp® Nutrigea formula contributes to balancing the psychophysiological response to mental stress, promoting clarity, stability, and adaptability over time. 100% vegan. Gluten-free.
The ingredients of the KlamUp® Nutrigea supplement can be useful as nutritional support in case of:
• Intense or prolonged psychophysical loads • Emotional tension and mental fatigue
• Period of reduced concentration, attention or cognitive continuity
• Particularly demanding periods of study or work
• Sensation of a decline in motivation or mental clarity
• Support for the natural neurofunctional processes associated with age
• Need to promote resilience and adaptation in conditions of prolonged pressure
Klamin® es from Klamath microalgae (Aphanizomenon flos aquae), Rhodiola rosea L. root es (3% total rosavins expressed as rosavin), bulking agent: acacia gum; pregelatinized corn starch, saffron (Crocus sativus L.) stigmas es (0.3% safranal), anti-caking agent: glycerol behenate; Lithothamnion calcareum algae thallus.
Do not exceed the recommended daily dose.
Keep out of reach of children under three years of age.
Supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
STORE IN A COOL, DRY PLACE.
1. G D. Scoglio, et al., (2024). The commercial potential of Aphanizomenon flos-aquae, a nitrogen-fixing edible cyanobacterium, Journal of Applied Phycology, Volume 36, pages 1593-1617 (2024).
2. Scoglio, G D. Scoglio, (2024) Klamath Lake Aphanizomenon Flos-Aquae: Wild-Harvesting, Extracts and Benefits. Vol. Insights Into Algae – Fundamentals, Culture Techniques and Biotechnological Uses of Microalgae and Cyanobacteria.
3. Nuzzo D, Presti G, Picone P, Galizzi G, Gulotta E, Giuliano S, Mannino C, Gambino V, Scoglio S, Di Carlo M (2018) Effects of the Aphanizomenon flos-aquae extract (klamin®) on a neurodegeneration cellular model. Oxidat Med Cell Longev 2018:9089016.
4. Genazzani AD, Chierchia E, Lanzoni C, Santagni S, Veltri F, Ricchieri F, Rattighieri E, Nappi RE (2010) Effects of Klamath Algae extract on psychological disorders and depression in menopausal women: a pilot study. Minerva Ginecology 62:381–388
5. Cremonte M, Sisti D, Maraucci I, Giribone S, Colombo E, Rocchi MBL, Scoglio S (2017) The effect of experimental supplementation with the klamath algae extract klamin on attention-deficit/hyperactivity disorder. J Med Food 20:1233–1239
6. Bellingeri P., Scoglio S., Bonucci M., (2018). Complementary Treatment of Mood Disturbances in Terminally Ill Oncological Patients with the Aphanizomenon Flos Aquae Extract Klamin®, Adv Complement Alt Med. 1(3).
7. Sedriep S. et al., (2011) Beneficial nutraceutical modulation of cerebral erythropoietin expression and oxidative stress: an experimental study, J Biol Regul Homeost Agents. 25(2):187-94.
8. Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S. (2012). Rhodiola rosea for physical and mental fatigue: a systematic review. BMC complementary and alternative medicine, 12(1), 70.
9. Ivanova Stojcheva, E., & Quintela, J. C. (2022). The effectiveness of rhodiola rosea L. Preparations in alleviating various aspects of life-stress symptoms and stress-induced conditions—encouraging clinical evidence. Molecules, 27(12), 3902.
10. Anghelescu, I. G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: a review. International journal of psychiatry in clinical practice, 22(4), 242-252.
11. Marx, W., Lane, M., Rocks, T., Ruusunen, A., Loughman, A., Lopresti, A., … & Dean, O. M. (2019). Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutrition reviews, 77(8), 557-571.
12. Shafiee, M., Arekhi, S., Omranzadeh, A., & Sahebkar, A. (2018). Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. Journal of Affective Disorders, 227, 330-337.
13. Ghaderi, A., Asbaghi, O., Reiner, Ž., Kolahdooz, F., Amirani, E., Mirzaei, H., … & Asemi, Z. (2020). The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complementary therapies in medicine, 48, 102250.
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